Transplantation in Chronic Lymphocytic Leukemia

Stem cell transplantation in chronic lymphocytic leukemia.

Chronic lymphocytic leukemia (CLL) remains incurable with standard therapy. Most patients with CLL have an indolent clinical course, but it is possible to identify patients with high-risk disease. Younger patients with adverse risk factors will die from their disease, and are therefore candidates for clinical trials exploring hematopoietic stem cell transplantation (HSCT). Autologous SCT is fea...

Stem Cell Transplantation in Chronic Lymphocytic Leukemia

Allogeneic Transplantation for Chronic Lymphocytic Leukemia

Even if Chronic lymphocytic leukemia (CLL) often has an indolent behavior with good responsiveness to cytoreductive treatment, about 20% of the patients, so called "poor-risk" patients, show an aggressive course and die within a few years despite early intensive therapies. Criteria for poor-risk disease according to the European Bone Marrow Transplantation (EBMT) CLL Transplant Consensus are: p...

The role of microRNA in acute/chronic, myeloid/lymphocytic leukemia

MicroRNAs are small, non-coding sequences that regulate gene expression by inducing degradation or translational inhibition of target mRNAs. These molecules control many intracellular physiological and pathological processes.Abnormal expression of these moleculs has been described in different cancers including hematopoietic cancers. According to the type of cancer and the stage, miRNA’s expres...

Transplantation in chronic lymphocytic leukemia: timing and expectations.

Stem cell transplantation in chronic lymphocytic leukemia (CLL) is an evolving field. Younger patients with high-risk disease might derive the greatest benefit from this approach and the availability of reduced-intensity conditioning regimens has made allogeneic stem cell transplantation more relevant to patients with CLL. Patient selection, timing of transplantation, and method of conditioning...